| Title | [Analysis of serum gastrin levels in patients with adenomatous polyps of the colon] | | Author(s) | Oset P, Jasińska A, Szcześniak P, Orszulak-Michalak D, Talar-Wojnarowska R, Małecka-Panas E | | Institution | Medical University of Łódź, Department of Digestive Tract Diseases. poset@op.pl | | Source | Pol Merkur Lekarski 2009 May; 26(155):458-61. | | Abstract | Adenomatous polyps are known risk factor of colon cancer. Gastrin is a peptide hormone involved in the growth of both normal and malignant intestinal tissue, which probably may promote progression through the adenoma-carcinoma sequence. AIM OF OUR STUDY: To assess the association between serum gastrin levels and size, type and localization of colonic adenomas.
MATERIAL AND METHODS: The study included 60 patients with adenomatous polyps of the colon and 30 healthy volunteers. Serum gastrin levels and presence of Helicobacter pylori infection were examined in all patients.
RESULTS: We observed higher serum gastrin levels in patients with colonic adenomas compared to control group (59.65 pg/ml vs. 46.89 pg/ml; p < 0.05). There was no association between gastrin levels and size, number, localisation and histologic type of polyps (p > 0.05). No differences between frequency of Helicobacter pylori infection and examined group of patients were observed (p > 0.05).
CONCLUSION: Despite of elevated serum levels in patients with colonic adenomas we did not observe the association between gastrin levels and size, grade of dysplasia and histologic type of polyps. The exact role of hipergastrinemia in process of colon carcinogenesis remains to be determined. | | Language | pol | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19606697 |
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